1.7 Ounces
Per Bottle
Recommended
2 Pumps
Liposomal
Face Cream
Renue Blue™ Face Cream with Methylene Blue, NAD⁺, NMN, NR (Liposomal)
$49.95
Renue Blue™ Face Cream is a multi-tasking powerhouse formulated to restore skin elasticity, increase youthful suppleness, preserve and rejuvenate skin’s surface & visibly enhance firmness.
2 mL (2 pumps) provides ▸100 mg NAD⁺ Complex ▸10 mg Resveratrol ▸10 mg Apocynin ▸ 500nM (.5μM) Methylene Blue Per Bottle 2 Pumps Face Cream
1.7 Ounces
Recommended
Liposomal
Coming soon!
NEW Renue Blue™ Liposomal Face Cream with Methylene Blue
Renue Blue™ Face Cream with Methylene Blue and NAD⁺ Complex, features our proprietary liposomal delivery system for faster and deeper penetration of key ingredients into the skin’s surface for deep cellular renewal.
Light, but deeply nourishing, this cream hydrates the skin and works as a protective shield against environmental factors. Bring your skin back to life with this fast-absorbing formula packed with Methylene Blue, NAD⁺, NMN, NR, Resveratrol, Apocynin, powerful marine-based nutrients, antioxidants and cell-renewing Alpha Lipoic Acid.
NAD⁺ COMPLEX
NAD⁺ Complex is a powerful trio, containing NAD⁺, NMN and NR. As you age, your skin requires higher levels of NAD⁺ to combat damage and keep your skin in a youthful and healthy state. Aging is directly associated with lower NAD⁺ levels in the skin. Delivery of NAD⁺ and NAD⁺ boosters through liposomal skincare is the optimal way to safely raise levels of NAD⁺ in the skin.
METHYLENE BLUE
Methylene Blue has been studied for a wide range of ailments, many of which are aging-related illnesses, and there are currently over 20,000 studies on Pubmed. One study conducted at the University of Maryland tested the potential dermal anti-aging benefits of four antioxidants, one of which was Methylene Blue.
Among all of the antioxidants studied, Methylene Blue was by far, the most effective.
University of Maryland Study
The study was conducted by the Department of Cell Biology & Molecular Genetics, at the University of Maryland.
In the study, researchers tested out four antioxidants on the skin, one of which was Methylene Blue. The second one was N. Acetyl Cysteine, or NAC, a very popular antioxidant, often taken as a supplement. The last two were MitoQ and mTEM - both of which are mitochondrial targeting antioxidants.
They applied each one topically to skin fibroblasts of healthy middle-aged adults, adults 80 and older and from people with progeria.
For most studies, skin fibroblasts are obtained through a non-invasive procedure that involves numbing at the site and taking a punch skin biopsy sample.
Progeria is an extremely rare genetic condition characterized by dramatic and rapid aging. It causes severe hardening of the arteries at a young age, and often those afflicted don't live past their teenage years.
Some researchers believe that Progeria may hold the key to understanding the precise causes of aging - so that it can be slowed down.
For this study, the Progeria fibroblasts were used as an accelerated model for normal aging - because they share many of the features in common with normal aging.
One part of the study looked at the effectiveness of these antioxidants to decrease oxidative stress. Oxidative stress plays a major role in the aging process in the skin, much of which is driven by UV exposure.
Among all of the antioxidants studied, Methylene Blue was the most effective.
It reduced mitochondrial reactive oxygen species, and promoted skin cell proliferation - which involves an increase in the cell division rate and that leads to a higher number of new, healthy cells created during cell turn-over.
The normal skin and the progeria skin treated with the Methylene Blue, showed much higher skin proliferation levels.
Research shows that as a person ages, proliferation of cells in the basal (or deepest) layer reduces. The epidermis (or the outer layer) then becomes thinner. The nutrition supply to the outer layer then weakens because of dysfunction in the deeper layers.
This process of decreased proliferation in the skin, is associated with senescence. Senescent cells, also known as zombie cells, can cause a lot of damage. They are cells that eventually stop multiplying, yet they don't die off like they should. Instead, they remain in the body and continue to release damaging chemicals that trigger inflammation.
In the second part of the study, cellular senescence was examined.
Different fibroblasts were used and treated with Methylene Blue. Two fibroblasts from people over 80 were used and two fibroblasts from people under 30 were used.
The over 80 fibroblasts showed increases in biomarkers of senescence. When treated with Methylene Blue, there was a reduction in cellular senescence, especially notable for the older skin fibroblasts. This showed that Methylene Blue is effective at reducing cellular senescence.
The study revealed that skin treated with Methylene Blue had an increase in skin thickness and improved levels of skin hydration.
This is important because skin thickness and loss of hydration are issues of aging skin. Dermal thickness decreases by about 6% every decade.
Among all of the antioxidants studied, Methylene Blue was the most effective.
The Methylene Blue-treated skin showed a greater reduction in DNA damage, leading to cell rejuvenation.
There was an increase the cell division rate, leading to a higher number of healthy new cells created during cellular turnover.
In addition, there was less senescence - and a slower rate of cell death, indicating that skin cells became healthier and lived longer.
There was also improved hydration levels and dermal thickness was increased.
Study: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity https://www.nature.com/articles/s41598-017-02419-3
Fighting against Skin Aging The Way from Bench to Bedside https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047276/
The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging https://sci-hub.do/10.1016/j.dnarep.2014.04.005
NAD in Skin: Therapeutic Approaches for Niacin https://sci-hub.do/10.2174/138161209787185760
Characteristics of the Aging Skin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/
Xiong, ZM, O’Donovan, M., Sun, L., et al. Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Sci Rep 7, 2475 (2017) (https://doi.org/10.1038/
RENUE™ - 2 Step Skin Rejuvenation Protocol
